Project
Biobehavioral Pain Reactivity in Infants with Prenatal Alcohol Exposure
Principal Investigator(s): Dr. Tim Oberlander, phone: 604-875-3570, email: toberlander@cw.bc.ca; Dr. Ruth Grunau, phone: 604-875-2447, email: rgrunau@cw.bc.ca; Dr. Joanne Weinberg, phone: 604-822-2316, email: joannew@interchange.ubc.ca; S. Jacobnson, phone: 313-993-5454; and J. Jacobsen, phone: 313-993-5454
Start/End Date: January 2005 - 2006
Location: Cape Town, South Africa; University of Stennenbosch and University of Cape Town
Brief Description: This is a sub study of neonatal pain reactivity and is part of a larger study funded by the National Institute on Alcohol Abuse and Alcoholism and the National Institute of Child Health and Human Development in the USA. The larger study entitled: “Assessing the Feasibility of a Prospective Study on the Role of Prenatal Alcohol Exposure in SIDS and Unexplained Stillbirth” is being conducted by Professor Hein Odendaal, from Stellenbosch University, Professor Christopher D. Molteno, from University of Cape Town, and Dr. Sandra W. Jacobson from Wayne State University in the United States.
In the larger study approximately 150 mothers will be recruited during their first prenatal care visit. All mothers presenting for prenatal care at one neighbourhood maternity obstetrical unit in Cape Town will be administered an alcohol history interview. All those who drink heavily will be invited to participate in the study. For each heavy drinking mother recruited, a lower level drinking or alcohol abstaining mother who has presented for prenatal care at the same point in gestation will also be recruited to participate. Mothers will be assigned a Study ID Number in numerical order and thusly cannot be identified as to group designation.
Mothers will be transported to the Obstetrics Department of the local hospital for fetal monitoring and to provide background information regarding diet, lifestyle, etc., 1-4 times during pregnancy, depending on when prenatal care was initiated. The mother and baby will be brought to the hospital for assessment 2-3 days post-delivery. The pain reactivity sub-study taking place around the BCG immunization for tuberculosis will be assessed at this first postnatal visit. Infants born at less than 36 weeks gestation will be excluded from this sub study. Additional follow-up assessments are planned at 6- and 12-months postpartum.
Time Frame: ongoing
Type of Project: research
Population Served: urban
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